ʻO nā Coenzymes he mau meaola kūlohelohe ʻole protein e pono ai no ka hana ʻana o nā enzymes he nui. Loaʻa ka hapa nui o lākou i nā huaora.
ʻO ke kumu o nā maʻi metabolic a me ka hōʻemi ʻana i ka synthesity o nā mea pono i loko o ke kino he emi pinepine i ka hana o kekahi mau ʻano ʻenekia. No laila, pono nui nā coenzymes iā mākou.
I ke ʻano haiki, coenzyme ka coenzyme Q10, kahi mea i loaʻa mai i ka waikawa folic a me kekahi mau huaora ʻē aʻe. ʻO ke koʻikoʻi nui no ke kino o ke kanaka kēlā mau coenzymes e hana ʻia e nā huaora B.
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Pono ka Coenzyme i mea e hoʻonui ai i ka hana o ka ikehu cellular, e pono ai e mālama i ke ola. ʻO kēlā me kēia kaʻina hana i loko o ke kino o ke kanaka e koi i kahi kumuwaiwai ikehu kolossal, he hana noʻonoʻo paha ia, ka hana o ka maʻi maʻi a me ka ʻōnaehana digestive, hoʻoikaika kino me ka ukana ma ka ʻōnaehana musculoskeletal. Ma muli o ka hopena e komo ai nā coenzymes me nā enzyme, hana ʻia ka ikehu e pono ai.
Nā hana o nā coenzymes
ʻO nā Coenzymes he mau protein non-proteinaceous e hāpai i ka hoʻoulu ʻana o ka hiki i ka enzyme. Hana lākou i nā hana nui 2:
- Komo i nā hana catalytic. ʻAʻole kumu ka coenzyme pono i nā hoʻololi kūmole pono i ke kino; komo ia i loko o ka hoʻohui o nā enzyme me ka apoenzyme, a ke hui pū lākou, hana nā hana catalytic o ka paʻa substrate.
- Kaʻa lawe. Hoʻohui pū ka coenzyme me ka substrate, e hopena ana i ke kahawai hoʻokele ikaika e neʻe manuahi ai nā mole i ke kikowaena o kekahi enzyme.
Loaʻa kahi waiwai nui o nā coenzymes āpau - he mau pūnaehana paʻa thermally ia, akā ʻokoʻa ʻokoʻa kā kā lākou hopena kemika.
Hoʻokaʻina o nā coenzymes
Wahi a nā ʻano o ka launa pū ʻana me ka apoenzyme, ua mahele ʻia nā coenzymes i:
- Wehe ʻia - i ka wā o ka hopena, hui pū ʻia me kahi mole o ka enzyme, a ma hope e loli i ka hoʻohui kemika a hoʻokuʻu hou ʻia.
- Prosthetic - pili paʻa me ka apoenzyme, i ka manawa o ka hopena i waenakonu o ka enzyme. Hana ʻia ko lākou regeneration ke hui pū me kekahi coenzyme a i ʻole substrate.
Wahi a kā lākou hanana kemika, ua mahele ʻia nā coenzymes i ʻekolu mau hui:
- aliphatic (glutathione, lipoic acid, a me nā mea ʻē aʻe)
- heterocyclic (pyridoxal phosphate, tetrahydrofolic acid, nucleoside phosphates a me kā lākou mea i loaʻa (CoA, FMN, FAD, NAD, a pēlā aku), metalloporphyrin hemes, etc.
- ʻala (ubiquinones).
Ma ka hana maʻamau, aia ʻelua mau pūʻulu o nā coenzymes:
- ʻulaʻula,
- hui coenzymes hoʻoili hui.
ʻO Coenzymes i ka pharmacology haʻuki
Me ka hoʻoikaika kino hoʻoikaika kino, pau ka nui o ka ikehu, hoʻopau ʻia kāna lako i ke kino, a he nui nā huaora a me nā meaola e hoʻopau wikiwiki ʻia ma mua o kā lākou hana. ʻIke nā mea pāʻani i ka nāwaliwali o ke kino, ka luhi o ka makaʻu, a me ka ikaika ʻole. I mea e kōkua ai i ka pale ʻana i nā ʻōuli he nui, ua hoʻomohala ʻia nā hoʻomākaukau kūikawā me nā coenzymes i ka hoʻohui. He ākea loa kā lākou laulā o ka hana, ua kuhikuhi ʻia lākou ʻaʻole wale i nā mea pāʻani, akā i nā poʻe me nā maʻi koʻikoʻi.
ʻO Cocarboxylase
ʻO Coenzyme, ka mea i hana ʻia mai ka thiamine e komo ana i ke kino. I ka poʻe haʻuki, lawelawe ia ma ke ʻano he mea pale i ka myocardial overstrain a me nā maʻi o ka ʻōnaehana ʻōnaehana. Kau ʻia ka lāʻau no ka radikulitis, neuritis, a me ka holo pono ʻole o ke ake. Lawe ʻia ia me ka intravenously, ʻaʻole pono ma lalo o 100 mg kahi mahele lāʻau hoʻokahi.
ʻO Cobamamide
Hoʻololi i ka hana o ka wikamina B12, he anabolic. Kōkua i nā mea pāʻani e kūkulu i ka puʻupuʻu, hoʻonui i ka hoʻomanawanui, paipai i ka wikiwiki wikiwiki ma hope o ka hoʻoikaika kino. Loaʻa i ke ʻano o nā papa a me nā hāʻina no ka lawelawe intravenous, ʻo ka helu o kēlā me kēia lā he 3 papa a 1000 mcg paha. ʻAʻole i ʻoi aku ka lōʻihi o ka papa ma mua o 20 mau lā.
ʻOxycobalamin
Ua like kāna hana me ka wikamina B12, akā noho mau ia i loko o ke koko aʻoi aku ka wikiwiki o ka hoʻololi ʻana i ʻano coenzyme ma muli o ka pili ikaika me nā protein plasma.
Pyridoxal phosphate
Loaʻa i ka hoʻomākaukau nā waiwai āpau o ka wikamina B6. ʻOkoʻa ia mai iā ia i kahi hopena therapeutic wikiwiki, ua kuhikuhi ʻia no ke komo ʻana inā ʻoiai ua hōʻino ʻia ka phyrorylation pyridoxine. Lawe ʻia ʻekolu mau manawa i ka lā, ʻaʻole ʻoi aku ka nui o nā lā ma mua o 0,06 g, a ʻaʻole ʻoi aku ka lōʻihi o ka papa ma mua o hoʻokahi mahina.
ʻO Pyriditol
Hoʻoulu ia i nā kaʻina hana metabolic o ka ʻōnaehana hopohopo waena, hoʻonui i ka permeability o glucose, pale i ka nui o ka hoʻokumu ʻia ʻana o ka lactic acid, hoʻonui i nā pono pale o nā aʻa, me ke kūʻē ʻana i ka hypoxia, i kū i ka wā o ka hoʻomaʻamaʻa haʻuki ikaika. Lawe ʻia ka lāʻau i ʻekolu mau manawa i ka lā, 0.1 g. ma hope o ka ʻaina kakahiaka no hoʻokahi mahina
Pantogam
He homologue ia o ka pantothenic acid, hōʻeleu i nā kaʻina hana metabolic, hoʻoliʻiliʻi i ka hōʻike ʻana o nā hopena ʻeha, hoʻonui i ke kūpaʻa o nā hunaola i hypoxia. Hoʻohana ka hana o ka lāʻau i ka hoʻoulu ʻana i ka hana o ka lolo, e hoʻonui ana i ka hoʻomanawanui, ua hōʻike ʻia ia no ka hoʻohana ʻana i nā ʻeha traumatic lolo o nā ʻano like ʻole. Lawe ʻia nā papa i loko o hoʻokahi mahina, 0.5 g, ʻaʻole i ʻoi aku ma mua o ʻekolu mau manawa o ka lā.
Carnitine
Hana ʻia ia i ke ʻano o ka lāʻau hoʻopī, ʻo ka hana i kau ʻia i ka hoʻoulu ʻana i ka momona momona, e wikiwiki ana i ka hoʻōla hou ʻana o ka pūnaewele. Loaʻa iā ia nā anabolic, antihypoxic a me nā hopena antithyroid. He pani synthetic ia no ka huaʻai B6. Kūpono e like me kahi drip intravenous.
Flavinate
Hana ʻia ia i loko o ke kino mai riboflavin a pili nui i ka carbohydrate, lipid a me ka amino acid metabolism. Hana ʻia ia i ke ʻano o ka hopena no ka hoʻopili ʻana i ka intramuscular, ʻoiai ka hopena ʻole o ka omo ʻana i loko o ka ʻōpū i ka hana ʻole i ka lawe ʻia o riboflavin.
ʻAkika lipoic
Hoʻonohonoho maʻamau i ka metabolism carbohydrate. Hoʻonui i ka helu o ka oxidation o nā haʻuki a me nā waikawa momona, e hāʻawi i ka hoʻonui i nā mālama ikehu.
